Editorial: Gene Therapy for the Central and Peripheral Nervous System

Editorial: Gene Therapy for the Central and Peripheral Nervous System

Gene therapy of central nervous system tumors.

Recently, remarkable advances have been achieved in molecular and genetic researches of different kinds of general diseases, as well as in basic and clinical studies using gene therapy for central nervous system diseases. For brain tumors, clinical trials have been already started in more than 10 clinical protocols and more than 100 patients with malignant brain tumors. Nevertheless, there are ...

Murine central and peripheral nervous system transcriptomes: comparative gene expression.

The central and peripheral nervous systems exhibit significant embryological, morphological, and functional differences. Moreover, the pathology of most acquired and hereditary neurological diseases preferentially targets specific components of the nervous system. In order to test the hypothesis that central and peripheral neural transcriptomes show fundamental quantitative differences, Affymet...

ADENOSINE IN THE CENTRAL NERVOUS SYSTEM

Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...

Receptors for gammaglobulin in the central and peripheral nervous system.

A heterogeneous group of receptors binding the Fc region of immunoglobulin (Ig), Fc receptors provide important links between the cellular and the humoral branches of the immune system. The members of this receptor group, specific for essentially all the Ig isotypes, are expressed on a variety of cells and mediate multiple important functions. Receptors for IgG (FcyR), a subgroup within the lar...